What are Exosomes?

Exosomes are tiny extracellular vesicles, basically nano-particles 30–150 nanometres in size naturally released by cells, especially stem cells. They contain bioactive molecules like proteins, lipids, mRNA, and microRNA, which are being used for various regenerative therapies — including hair restoration.

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How does Exosomes Work for Hair Loss:

Mesenchymal Stem Cells (MSC)-derived exosomes are rich in growth factors, cytokines, and genetic material that stimulate hair follicle regeneration and reduce inflammation.

They promote the proliferation of hair follicle cells, enhance blood circulation to the scalp, and can improve scalp health. Exosome therapy can also help prolong the anagen (growth) phase of the hair cycle.

How does Exosomes Promote Hair Growth:

Stimulate Hair Follicle Activity:

Exosomes can promote hair growth by stimulating dermal papilla cells and activating hair follicle stem cells. They enhance proliferation of dermal papilla cells, crucial for hair cycling. Thus, they can reactivate dormant hair follicles and promote the entry of follicles into the anagen (growth) phase of the hair cycle.

Improve Blood Circulation:

Exosomes may promote angiogenesis (new blood vessel formation), improving nutrient delivery to hair follicles. Exosomes can enhance blood flow to the scalp, providing nutrients and oxygen to hair follicles.

Reduce Inflammation:

Chronic inflammation (e.g., in alopecia areata or androgenetic alopecia) can damage hair follicles. Exosomes have anti-inflammatory effects that may protect follicles. They help to reduce inflammation in the scalp, which can contribute to hair loss. They can modulate inflammatory responses, creating a more favourable environment for hair growth.

Extend Hair Growth Phase (Anagen Phase):

By modulating signalling pathways (e.g., Wnt/β-catenin), exosomes may prolong the active growth phase of hair.

Repair Damaged Scalp Tissue:

Exosomes support tissue regeneration, which can help in cases of scarring alopecia or damage from harsh treatments.

Deliver growth factors:

Exosomes carry growth factors and other signalling molecules directly to hair follicles, stimulating cell proliferation and differentiation. Growth factors like VEGF, FGF, and IGF-1, which support follicle growth and prolong the anagen (growth) phase.

Targeted delivery:

Exosomes can be delivered directly to the affected area, leading to more effective and targeted treatment.

Enhances Scalp Health:

Exosome therapy can improve the overall health of the scalp by promoting blood circulation and providing nutrients to hair follicles.

Who are the ideal candidates for Exosome Therapy ?

People suffering from –
Androgenic Alopecia
Female Patterned Hair Loss
Alopecia Areata
Telogen Effluvium
Diffuse Unpatterned Alopecia
Scalp Inflammation

How is Exosome Therapy Administered for Hair Loss?

Microneedling + Exosomes – Enhances penetration into the scalp for better follicle stimulation. A derma pen is used to help infuse the exosomes into a depth of around 1.5-2 mm inside the skin, to help them reach the ideal depth where they can promote regrowth of hair.

The downtime is next to none, with the patient needing virtually no pre-procedure or post-procedure precautions.

How many Exosome Therapy sessions are needed?

While results like reduced hair loss, increased density and thickness can be visible after 1-2 sessions, for long lasting and best possible results it is important to take 5-6 sessions at and interval of 1 month each.

Evidence & Effectiveness –

Studies suggest exosomes can increase hair density and thickness, particularly in androgenetic alopecia and alopecia areata. Clinical results may take 2–6 months to appear Combination with PRP or GFC may enhance results, as exosomes can amplify growth signals.